The Daphne project ‘Prevent and Combat Child Abuse: What works? An overview of regional approaches, exchange and research’ aimed to bring together knowledge and practice on what works in the full range of tackling child abuse. This project was funded by the European Commission. It was coordinated by the Netherlands Youth Institute and carried out in collaboration with the Swedish Orebro regional council, the Hungarian Family child Youth Association, the German Youth Institute, CESIS from Portugal and the Verweij-Jonker Institute from The Netherlands. Participating countries shared their knowledge from five national reports. Partners also collected practice-based knowledge on tackling abuse and neglect in all five countries. Coordinated by the Verwey-Jonker Institute from the Netherlands, a study was carried out by partners among parents and professionals – based on a limited sample – in Germany, Hungary, Portugal, Sweden and The Netherlands. The foundation of the manual is article 19 of the Convention of the Rights of the Child, in particular the related General Comment 13: the right of the child to freedom from all forms of violence. Not only does this General Comment apply to all countries and parties involved, it also outlines a coherent and effective framework for research, policy and practice. But like most international recommendations and standards, it is very general and we hope that this manual ‘What works in tackling child abuse and neglect’?’ can contribute to making a next step towards its implementation. After comparing the ideal situation represented by the General Comment with the evidence and practice-based knowledge regarding the quality of the systems, services and professionals, specific conclusions and recommendations were formulated regarding the various steps in the care continuum around child abuse: • Universal and targeted prevention; • Detecting, reporting and stopping child abuse; • Treatment and out-of-home placement. Additional conclusions and recommendations focus on integrated working in relation to tackling child abuse and neglect. Many of these recommendations have been made before, but some messages have to be repeated over and over again, before they become reality.