The purpose of this report is to develop an evaluation framework for USAID prevention and victim protection programs that address trafficking in persons (TIP). An evaluation framework is an analytic tool designed to provide technical guidance for meaningful, reliable, and valid evaluation of specific program outcomes and impact. Prevention programs support campaigns focusing on public awareness, education, advocacy, income generation, and demand reduction. Protection and victim assistance programs provide shelters and targeted services for identified and potential victims of trafficking. Although there is near universal agreement about the fact that we must improve the impact evaluation of anti-TIP programs in order to enhance understanding of what works and what does not, limited information is available on how to do this. The purpose of this report, therefore, is to provide concrete guidance on how to evaluate anti-TIP programs to those who are designing and implementing such programs.